The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mammary tumor suppression by transforming growth factor beta 1 transgene expression.
Open accessAbstract
In cell culture, type alpha transforming growth factor (TGF-alpha) stimulates epithelial cell growth, whereas TGF-beta 1 overrides this stimulatory effect and is growth inhibitory. Transgenic mice that overexpress TGF-alpha under control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary ductal hyperplasia and stochastic development of mammary carcinomas, a process that can be accelerated by administration of the chemical carcinogen 7,12-dimethylbenz[a]anthracene. MMTV-TGF-beta 1 transgenic mice display mammary ductal hypoplasia and do not develop mammary tumors. We report that in crossbreeding experiments involving the production of mice carrying both the MMTV-TGF-beta 1 and MMTV-TGF-alpha transgenes, there is marked suppression of mammary tumor formation and that MMTV-TGF-beta 1 transgenic mice are resistant to 7,12-dimethylbenz[a]anthracene-induced mammary tumor formation. These data demonstrate that overexpression of TGF-beta 1 in vivo can markedly suppress mammary tumor development.
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Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
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Metadata
- Authors
- Pierce, D. F., Gorska, A. E., Chytil, A., Meise, K. S., Page, D. L., Coffey, R. J., & Moses, H. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-09
- Volume
- 92
- Issue
- 10
- Pages
- 4254-4258
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156022038
- Cited by
- 291
- References
- 1
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Pierce, D. F., Gorska, A. E., Chytil, A., Meise, K. S., Page, D. L., Coffey, R. J., & Moses, H. L. (1995). Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.10.4254
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