The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
bcl-2 transgene expression can protect neurons against developmental and induced cell death.
Open accessAbstract
The bcl-2 protooncogene, which protects various cell types from apoptotic cell death, is expressed in the developing and adult nervous system. To explore its role in regulation of neuronal cell death, we generated transgenic mice expressing Bcl-2 under the control of the neuron-specific enolase promoter, which forced expression uniquely in neurons. Sensory neurons isolated from dorsal root ganglia of newborn mice normally require nerve growth factor for their survival in culture, but those from the bcl-2 transgenic mice showed enhanced survival in its absence. Furthermore, apoptotic death of motor neurons after axotomy of the sciatic nerve was inhibited in these mice. The number of neurons in two neuronal populations from the central and peripheral nervous system was increased by 30%, indicating that Bcl-2 expression can protect neurons from cell death during development. The generation of these transgenic mice suggests that Bcl-2 may play an important role in survival of neurons both during development and throughout adult life.
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Cites
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Cited by
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111
Strasser, A., O'Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,351
Life, death, and the pursuit of apoptosis.
White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,311
Pettmann, B., & Henderson, C. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81004-1 · Cited by 592
Whitfield, J., Neame, S. J., Paquet, L., Bernard, O., & Ham, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00239-2 · Cited by 565
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Metadata
- Authors
- Farlie, P. G., Dringen, R., Rees, S. M., Kannourakis, G., & Bernard, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-09
- Volume
- 92
- Issue
- 10
- Pages
- 4397-4401
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016446826
- Cited by
- 252
- References
- 5
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Farlie, P. G., Dringen, R., Rees, S. M., Kannourakis, G., & Bernard, O. (1995). bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.10.4397
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