The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bclx regulates the survival of double-positive thymocytes.
Open accessAbstract
The bclx gene has been shown to regulate programmed cell death in vitro. We now show that Bclx expression increases dramatically when T cells differentiate from CD4- CD8- (double negative) thymocytes to CD4+ CD8+ [double positive (DP)] thymocytes. In contrast single-positive (SP) thymocytes express negligible amounts of Bclx protein. This expression pattern contrasts with that of Bcl2, which is present in double-negative thymocytes, down-regulated in DP thymocytes, and reinduced upon maturation to SP thymocytes. Elimination of Bclx by gene targeting dramatically shortens the survival of DP thymocytes but not the survival of SP thymocytes or peripheral SP T cells. These data suggest that the induction of Bclx during thymic maturation plays a critical role in regulating the length of time DP thymocytes survive in the absence of selection.
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Cites
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899
Cited by
DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS
Ma, A., Koka, R., & Burkett, P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090727 · Cited by 829
Self-citationMultiple Bcl-2 family members demonstrate selective dimerizations with Bax.
Sedlak, T. W., Oltvai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B., & Korsmeyer, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7834 · Cited by 816
Self-citationDevelopment and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Opferman, J. T., Letai, A., Beard, C., Sorcinelli, M. D., Ong, C. C., & Korsmeyer, S. J. (2003) · Nature · doi:10.1038/nature02067 · Cited by 801
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., & Strasser, A. (2002) · Nature · doi:10.1038/415922a · Cited by 782
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 673
Metadata
- Authors
- Ma, A., Pena, J. C., Chang, B., Margosian, E., Davidson, L., Alt, F. W., & Thompson, C. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-23
- Volume
- 92
- Issue
- 11
- Pages
- 4763-4767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2083717129
- Cited by
- 244
- References
- 3
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Ma, A., Pena, J. C., Chang, B., Margosian, E., Davidson, L., Alt, F. W., & Thompson, C. B. (1995). Bclx regulates the survival of double-positive thymocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.11.4763
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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