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Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
Open accessAbstract
We describe a protein kinase, Shk1, from the fission yeast Schizosaccharomyces pombe, which is structurally related to the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases. We provide genetic evidence for physical and functional interaction between Shk1 and the Cdc42 GTP-binding protein required for normal cell morphology and mating in S. pombe. We further show that expression of the STE20 gene complements the shk1 null mutation and that Shk1 is capable of signaling to the pheromone-responsive mitogen-activated protein kinase cascade in S. cerevisiae. Our results lead us to propose that signaling modules composed of small GTP-binding proteins and protein kinases related to Shk1, Ste20, and p65PAK, are highly conserved in evolution and participate in both cytoskeletal functions and mitogen-activated protein kinase signaling pathways.
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Citations
Cited by
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Van Aelst, L., & D’Souza-Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases
Burbelo, P. D., Drechsel, D., & Hall, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29071 · Cited by 622
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M., & Chernoff, J. (1997) · Current Biology · doi:10.1016/s0960-9822(97)70091-5 · Cited by 603
Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T., & Lim, L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1129 · Cited by 561
Metadata
- Authors
- Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M. H., & Wigler, M. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-06-20
- Volume
- 92
- Issue
- 13
- Pages
- 6180-6184
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088822716
- Cited by
- 165
- References
- 0
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. https://app.cochat.ai/papers/10.1073/pnas.92.13.6180
- The paper
- Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M. H., & Wigler, M. H. (1995). Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.13.6180
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