The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cotranslational folding and calnexin binding during glycoprotein synthesis.
Open accessAbstract
To analyze cotranslational folding of influenza hemagglutinin in the endoplasmic reticulum of live cells, we used short pulses of radiolabeling followed by immunoprecipitation and analysis with a two-dimensional SDS/polyacrylamide gel system which was nonreducing in the first dimension and reducing in the second. It separated nascent glycopolypeptides of different length and oxidation state. Evidence was obtained for cotranslational disulfide formation, generation of conformational epitopes, N-linked glycosylation, and oligosaccharide-dependent binding of calnexin, a membrane-bound chaperone that binds to incompletely folded glycoproteins via partially glucose-trimmed oligosaccharides. When glycosylation or oligosaccharide trimming was inhibited, the folding pathway was perturbed, suggesting a role for N-linked oligosaccharides and calnexin during translation of hemagglutinin.
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Hammond, C., Braakman, I., & Helenius, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.913 · Cited by 841
Self-citation
Cited by
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
Self-citationN-glycan structures: recognition and processing in the ER
Aebi, M., Bernasconi, R., Clerc, S., & Molinari, M. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.001 · Cited by 489
ER chaperone functions during normal and stress conditions
Ma, Y., & Hendershot, L. M. (2004) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.08.007 · Cited by 440
Recombination of protein domains facilitated by co-translational folding in eukaryotes
Netzer, W. J., & Hartl, F. U. (1997) · Nature · doi:10.1038/41024 · Cited by 407
Molecular confinement influences protein structure and enhances thermal protein stability
Eggers, D. K., & Valentine, J. S. (2001) · Protein Science · doi:10.1110/ps.36201 · Cited by 393
Metadata
- Authors
- Chen, W., Helenius, J., Braakman, I., & Helenius, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-07-03
- Volume
- 92
- Issue
- 14
- Pages
- 6229-6233
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089621623
- Cited by
- 242
- References
- 1
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, W., Helenius, J., Braakman, I., & Helenius, A. (1995). Cotranslational folding and calnexin binding during glycoprotein synthesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.14.6229
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