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Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.
Open accessAbstract
Glial cell line-derived neurotrophic factor (GDNF) has been shown to rescue developing motoneurons in vivo and in vitro from both naturally occurring and axotomy-induced cell death. To test whether GDNF has trophic effects on adult motoneurons, we used a mouse model of injury-induced adult motoneuron degeneration. Injuring adult motoneuron axons at the exit point of the nerve from the spinal cord (avulsion) resulted in a 70% loss of motoneurons by 3 weeks following surgery and a complete loss by 6 weeks. Half of the loss was prevented by GDNF treatment. GDNF also induced an increase (hypertrophy) in the size of surviving motoneurons. These data provide strong evidence that the survival of injured adult mammalian motoneurons can be promoted by a known neurotrophic factor, suggesting the potential use of GDNF in therapeutic approaches to adult-onset motoneuron diseases such as amyotrophic lateral sclerosis.
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Cited by
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Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Trupp, M., Belluardo, N., Funakoshi, H., & Ibáñez, C. F. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03554.1997 · Cited by 503
Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse
Golden, J. P., DeMaro, J. A., Osborne, P. A., Milbrandt, J., & Johnson, E. M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7127 · Cited by 360
Höke, A., Gordon, T., Zochodne, D. W., & Sulaiman, O. A. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7826 · Cited by 301
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Metadata
- Authors
- Li, L., Wu, W., Lin, L. F., Lei, M., Oppenheim, R. W., & Houenou, L. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-10-10
- Volume
- 92
- Issue
- 21
- Pages
- 9771-9775
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2092357265
- Cited by
- 341
- References
- 0
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. https://app.cochat.ai/papers/10.1073/pnas.92.21.9771
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- Li, L., Wu, W., Lin, L. F., Lei, M., Oppenheim, R. W., & Houenou, L. J. (1995). Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.21.9771
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
