The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Steroid receptor heterodimerization demonstrated in vitro and in vivo.
Open accessAbstract
The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members of the intracellular receptor superfamily that bind as homodimers to the same hormone response elements (HREs). Physiological evidence suggests that MR and GR interact with each other in cells that express both receptors, implying that they might directly interact in the regulation of transcription initiation. Indeed, we have found that coexpressed MR and GR interact functionally at the transcriptional level and furthermore that they interact physically through heterodimer formation at a shared HRE in vitro and in vivo. We suggest from these findings that heterodimerization may play an important role in steroid receptor transcriptional regulation.
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Cites
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503
Vinson, C. R., Hai, T., & Boyd, S. M. (1993) · Genes & Development · doi:10.1101/gad.7.6.1047 · Cited by 336
Cited by
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489
GLUCOCORTICOID AND MINERALOCORTICOID RECEPTORS: Biology and Clinical Relevance
Funder, M. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.231 · Cited by 320
Multiple aspects of mineralocorticoid selectivity
Farman, N., & Rafestin-Oblin, M.-E. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.2.f181 · Cited by 268
Metadata
- Authors
- Liu, W., Wang, J., Sauter, N. K., & Pearce, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-12-19
- Volume
- 92
- Issue
- 26
- Pages
- 12480-12484
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003196551
- Cited by
- 243
- References
- 2
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, W., Wang, J., Sauter, N. K., & Pearce, D. (1995). Steroid receptor heterodimerization demonstrated in vitro and in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.26.12480
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