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Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.
Open accessAbstract
Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is significantly higher in patients with myocardial infarction before the age of 45 than in population-based controls (allele frequencies of 0.63 vs. 0.53). Both alleles bind a transcriptional activator, whereas the 5G allele also binds a repressor protein to an overlapping binding site. In the absence of bound repressor, the basal level of PAI-1 transcription is increased.
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Citations
Cited by
Lohmueller, K. E., Pearce, C. L., Pike, M., Lander, E. S., & Hirschhorn, J. N. (2003) · Nature Genetics · doi:10.1038/ng1071 · Cited by 1,900
Wood, D., De Backer, G., Faergeman, O., Graham, I., Mancia, G., & Pyörälä, K. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)90209-x · Cited by 1,255
Prediction of the Risk of Myocardial Infarction from Polymorphisms in Candidate Genes
Yamada, Y., Izawa, H., Ichihara, S., Takatsu, F., Ishihara, H., Hirayama, H., Sone, T., Tanaka, M., & Yokota, M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021445 · Cited by 640
Ye, Z., Liu, E. H., Higgins, J. P., Keavney, B. D., Lowe, G. D., Collins, R., & Danesh, J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68263-9 · Cited by 411
The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
Metadata
- Authors
- Eriksson, P., Kallin, B., van 't Hooft, F. M., Båvenholm, P., & Hamsten, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-14
- Volume
- 92
- Issue
- 6
- Pages
- 1851-1855
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965430426
- Cited by
- 739
- References
- 0
- FWCI
- 16.04
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. https://app.cochat.ai/papers/10.1073/pnas.92.6.1851
- The paper
- Eriksson, P., Kallin, B., van 't Hooft, F. M., Båvenholm, P., & Hamsten, A. (1995). Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.6.1851
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
