The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.
Open accessAbstract
From breast cancer cDNA libraries, we have cloned cDNAs that proved to correspond to the membrane-type matrix metalloproteinase (MT-MMP) recently identified in human placenta and proposed to be an activator of progelatinase A [Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. & Seiki, M. (1994) Nature (London) 370, 61-65]. Using one of these cDNAs as a probe, we have detected MT-MMP gene expression in all 83 human carcinoma specimens examined by RNA in situ hybridization and have found MT-MMP transcripts in fibroblastic cells of tumor stroma but not in cancer cells. Comparison with other MMP genes expressed in fibroblastic cells of human carcinomas indicated that the expression pattern of the MT-MMP gene was more closely related to that of the gelatinase A gene than to those of the stromelysin 3 or interstitial collagenase genes. These observations are consistent with the hypothesis that MT-MMP and gelatinase A are cooperating during tumor progression and strengthen the concept that proteolytic activities originating from the stromal component of human carcinomas have a critical role in tumor progression.
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Cites
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Cited by
Matrix metalloproteinase inhibitors
Wojtowicz-Praga, S. M., Dickson, R. B., & Hawkins, M. J. (1997) · Investigational New Drugs · doi:10.1023/a:1005722729132 · Cited by 518
Nakahara, H., Howard, L., Thompson, E. W., Sato, H., Seiki, M., Yeh, Y., & Chen, W.-T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7959 · Cited by 425
Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion
Seiki, M. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00699-7 · Cited by 406
Structural properties of matrix metalloproteinases
Bode, W., Fernandez-Catalan, C., Grams, H. T., & Maskos, H. N. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050320 · Cited by 329
Fernandez‐Catalan, C., Bode, W., Huber, R., Turk, D., Calvete, J. J., Lichte, A., Tschesche, H., & Maskos, K. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5238 · Cited by 321
Metadata
- Authors
- Okada, A., Bellocq, J. P., Rouyer, N., Chenard, M. P., Rio, M. C., Chambon, P., & Basset, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-28
- Volume
- 92
- Issue
- 7
- Pages
- 2730-2734
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048172586
- Cited by
- 499
- References
- 1
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. https://app.cochat.ai/papers/10.1073/pnas.92.7.2730
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- Okada, A., Bellocq, J. P., Rouyer, N., Chenard, M. P., Rio, M. C., Chambon, P., & Basset, P. (1995). Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.7.2730
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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