The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains.
Open accessAbstract
The regulated expression of neural cell adhesion molecule (NCAM) isoforms in the brain is critical for many neurodevelopmental processes including neurulation, axonal outgrowth, and the establishment of neuronal connectivity. We have investigated the expression of the major adult isoforms of NCAM (NCAM-180, NCAM-140, and NCAM-120) and its embryonic highly polysialylated isoform (PSA-NCAM) in the hippocampal region of postmortem brains from 10 schizophrenic and 11 control individuals. Immunohistochemical analysis with a monoclonal antibody recognizing the PSA-NCAM revealed immunoreactivity primarily in the dentate gyrus and in a subset of cells in the hilus region. We have observed a 20-95% reduction in the number of hilar PSA-NCAM-immunoreactive cells in the great majority of schizophrenic brains. The change in PSA-NCAM immunoreactivity is not obvious in other hippocampal subfields. Western blots of tissues from the hippocampal region (as well as from the frontal cortex) probed with a polyclonal antibody recognizing all NCAM isoforms did not reveal significant changes in the overall expression of NCAM, suggesting that the decrease in PSA-NCAM-immunoreactive cells may be related to post-translational processing of the molecule. The expression of this embryonic form of NCAM has been proposed to be related to synaptic rearrangement and plasticity. Therefore, the decrease in PSA-NCAM immunoreactivity in schizophrenic hippocampi may suggest an altered plasticity of this structure in a large proportion of schizophrenic brains. These findings may bear significance to the "neurodevelopmental hypothesis" of schizophrenia.
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Cites
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180
Cunningham, B. A., Hemperly, J. J., Murray, B. A., Prediger, E. A., Brackenbury, R., & Edelman, G. M. (1987) · Science · doi:10.1126/science.3576199 · Cited by 1,117
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086
Cremer, H., Lange, R., Christoph, A., Plomann, M., Vopper, G., Roes, J., Brown, R., Baldwin, S., Kraemer, P., Scheff, S., et al. (1994) · Nature · doi:10.1038/367455a0 · Cited by 1,007
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 890
Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons
Dodd, J., Morton, S. B., Karagogeos, D., Yamamoto, M., & Jessell, T. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90194-8 · Cited by 741
CELL ADHESION MOLECULES: Implications for a Molecular Histology
Edelman, G. M., & Crossin, K. L. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001103 · Cited by 705
Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.44 · Cited by 697
Akbarian, S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150007001 · Cited by 678
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.7.890 · Cited by 668
Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
Friston, K. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00140-0 · Cited by 882
Schnaar, R. L., Gerardy-Schahn, R., & Hildebrandt, H. (2014) · Physiological Reviews · doi:10.1152/physrev.00033.2013 · Cited by 745
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650
Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
Rutishauser, U. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2285 · Cited by 584
Metadata
- Authors
- Barbeau, D., Liang, J. J., Robitalille, Y., Quirion, R., & Srivastava, L. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-28
- Volume
- 92
- Issue
- 7
- Pages
- 2785-2789
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080949300
- Cited by
- 332
- References
- 39
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Barbeau, D., Liang, J. J., Robitalille, Y., Quirion, R., & Srivastava, L. K. (1995). Decreased expression of the embryonic form of the neural cell adhesion molecule in schizophrenic brains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.7.2785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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