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Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure.
Open accessAbstract
The potential contribution of recombination to the development of HIV-1 resistance to multiple drugs was investigated. Two distinct viruses, one highly resistant to a protease inhibitor (SC-52151) and the other highly resistant to zidovudine, were used to coinfect T lymphoblastoid cells in culture. The viral genotypes could be distinguished by four mutations conferring drug resistance to each drug and by other sequence differences specific for each parental virus. Progeny virions recovered from mixed infection were passaged in the presence and absence of both zidovudine and SC-52151. Dually resistant mutants emerged rapidly under selective conditions, and these viruses were genetic recombinants. These results emphasize that genetic recombination could contribute to high-level multiple-drug resistance and that this process must be considered in chemotherapeutic strategies for HIV infection.
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Cites
Temin, H. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6900 · Cited by 309
Cited by
Domingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Potential factors affecting adherence with HIV therapy
Mehta, S., Moore, R. D., & Graham, N. M. H. (1997) · AIDS · doi:10.1097/00002030-199714000-00002 · Cited by 324
Recombination in Evolutionary Genomics
Posada, D., Crandall, K. A., & Holmes, E. C. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.040202.111115 · Cited by 305
Accurately Measuring Recombination between Closely Related HIV-1 Genomes
Schlub, T. E., Smyth, R. P., Grimm, A. J., Mak, J., & Davenport, M. P. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000766 · Cited by 64
Metadata
- Authors
- Moutouh, L., Corbeil, J., & Richman, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-11
- Volume
- 93
- Issue
- 12
- Pages
- 6106-6111
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970335365
- Cited by
- 235
- References
- 1
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Moutouh, L., Corbeil, J., & Richman, D. D. (1996). Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.12.6106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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