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Cited by 696

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Bootstrap confidence levels for phylogenetic trees.

Open access
Efron, B, Halloran, E, Holmes, S·1996·Proceedings of the National Academy of Sciences

Abstract

Evolutionary trees are often estimated from DNA or RNA sequence data. How much confidence should we have in the estimated trees? In 1985, Felsenstein [Felsenstein, J. (1985) Evolution 39, 783-791] suggested the use of the bootstrap to answer this question. Felsenstein's method, which in concept is a straightforward application of the bootstrap, is widely used, but has been criticized as biased in the genetics literature. This paper concerns the use of the bootstrap in the tree problem. We show that Felsenstein's method is not biased, but that it can be corrected to better agree with standard ideas of confidence levels and hypothesis testing. These corrections can be made by using the more elaborate bootstrap method presented here, at the expense of considerably more computation.

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Metadata

Authors
Efron, B., Halloran, E., & Holmes, S.
Venue
Proceedings of the National Academy of Sciences
Published
1996-07-09
Volume
93
Issue
14
Pages
7085-7090
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2019032222
Cited by
696
References
1
FWCI
2.85
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Bootstrap confidence levels for phylogenetic trees. https://app.cochat.ai/papers/10.1073/pnas.93.14.7085
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Efron, B., Halloran, E., & Holmes, S. (1996). Bootstrap confidence levels for phylogenetic trees. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.14.7085

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