The DOI matches its Crossref record.
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.
Open accessAbstract
The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.
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Cited by
Poly(ADP-ribose): novel functions for an old molecule
Schreiber, V., Dantzer, F., Ame, J.-C., & de Murcia, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,915
Self-citationTankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres
Smith, S., Giriat, I., Schmitt, A., & de Lange, T. (1998) · Science · doi:10.1126/science.282.5393.1484 · Cited by 1,012
Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1
Langelier, M.-F., Planck, J. L., Roy, S., & Pascal, J. M. (2012) · Science · doi:10.1126/science.1216338 · Cited by 665
Hassa, P. (2008) · Frontiers in Bioscience · doi:10.2741/2909 · Cited by 584
Parthanatos, a messenger of death
David, K. K. (2009) · Frontiers in Bioscience · doi:10.2741/3297 · Cited by 450
“The crystal structure of the catalytic domain of chicken PARP-1 shows structural homology with the active site of bacterial ADP-ribosylating toxins (3).”
Background
Metadata
- Authors
- Ruf, A., Mennissier de Murcia, J., de Murcia, G., & Schulz, G. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-23
- Volume
- 93
- Issue
- 15
- Pages
- 7481-7485
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978367221
- Cited by
- 241
- References
- 0
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken. https://app.cochat.ai/papers/10.1073/pnas.93.15.7481
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- Ruf, A., Mennissier de Murcia, J., de Murcia, G., & Schulz, G. E. (1996). Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.15.7481
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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