The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.
Open accessAbstract
The RXR gamma (RXR, retinoid X receptor) gene was disrupted in the mouse. Homozygous mutant mice developed normally and were indistinguishable from their RXR gamma +/- or wild-type littermates with respect to growth, fertility, viability, and apparent behavior in the animal facility. Moreover, RXR alpha -/-/RXR gamma -/- and RXR beta -/-/RXR gamma -/- mutant phenotypes were indistinguishable from those of RXR alpha -/- and RXR beta -/- mutants, respectively. Strikingly, RXR alpha +/-/RXR beta -/-/RXR gamma -/- triple mutants were viable. Thus, it appears that RXR gamma does not exert any essential function that cannot be performed by RXR alpha or RXR beta, and one copy of RXR alpha is sufficient to perform most of the functions of the RXRs.
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Citations
Cites
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821
Self-citation
Cited by
Retinoid X receptor gamma signaling accelerates CNS remyelination
Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547
Self-citationRAR and RXR modulation in cancer and metabolic disease
Altucci, L., Leibowitz, M. D., Ogilvie, K. M., de Lera, A. R., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2397 · Cited by 517
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
Self-citationT HE R OLE OF V ITAMIN A IN M AMMALIAN R EPRODUCTION AND E MBRYONIC D EVELOPMENT
Clagett-Dame, M., & DeLuca, H. F. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102745e · Cited by 461
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439
“RAR/RXR heterodimers form the functional unit that transduces the RA signal, with one genomic copy of the Rxrα sufficient to support RXR function in embryogenesis [105].”
Background
Metadata
- Authors
- Krezel, W., Dupé, V, Mark, M., Dierich, A., Kastner, P., & Chambon, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-08-20
- Volume
- 93
- Issue
- 17
- Pages
- 9010-9014
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037917220
- Cited by
- 216
- References
- 1
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. https://app.cochat.ai/papers/10.1073/pnas.93.17.9010
- The paper
- Krezel, W., Dupé, V, Mark, M., Dierich, A., Kastner, P., & Chambon, P. (1996). RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.17.9010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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