The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis.
Open accessAbstract
The receptor tyrosine kinase RET functions during the development of the kidney and the enteric nervous system, yet no ligand has been identified to date. This report demonstrates that the glial cell line-derived neurotrophic factor (GDNF) activates RET, as measured by tyrosine phosphorylation of the intracellular catalytic domain. GDNF also binds RET with a dissociation constant of 8 nM, and 125I-labeled GDNF can be coimmunoprecipitated with anti-RET antibodies. In addition, exogenous GDNF stimulates both branching and proliferation of embryonic kidneys in organ culture, whereas neutralizing antibodies against GDNF inhibit branching morphogenesis. These data indicate that RET and GDNF are components of a common signaling pathway and point to a role for GDNF in kidney development.
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Cites
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
Tomac, A., Lindqvist, E., Lin, L.-F. H., Ögren, S. O., Young, D., Hoffer, B. J., & Olson, L. (1995) · Nature · doi:10.1038/373335a0 · Cited by 1,079
Cited by
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Six1 is required for the early organogenesis of mammalian kidney
Xu, P.-X., Zheng, W., Huang, L., Maire, P., Laclef, C., & Silvius, D. (2003) · Development · doi:10.1242/dev.00536 · Cited by 361
Cessation of renal morphogenesis in mice
Hartman, H. A., Lai, H. L., & Patterson, L. T. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.021 · Cited by 305
Metadata
- Authors
- Vega, Q. C., Worby, C. A., Lechner, M. S., Dixon, J. E., & Dressler, G. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-10
- Volume
- 93
- Issue
- 20
- Pages
- 10657-10661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052106777
- Cited by
- 242
- References
- 1
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Vega, Q. C., Worby, C. A., Lechner, M. S., Dixon, J. E., & Dressler, G. R. (1996). Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.20.10657
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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