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The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila
Open accessAbstract
It has long been suspected that proteolytic activity associated with advancing growth cones may be required for axon extension. We have isolated mutations in the kuzbanian ( kuz ) gene, which is expressed in the nervous system and encodes a putative zinc metalloprotease with a disintegrin domain. Drosophila embryos with loss-of-function mutations in kuz have dramatic defects in the development of central nervous system axon pathways, with many axons stalling and failing to extend through the nerve cord. This phenotype is rescued by panneural expression of kuz mRNA in the embryo. These results show that the Kuz metalloprotease is required for axon extension, suggesting a requirement for proteolytic activity at the growth cone surface.
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Wolfsberg, T. G., Primakoff, P., Myles, D. G., & White, J. M. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.2.275 · Cited by 502
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Metadata
- Authors
- Fambrough, D., Pan, D., Rubin, G. M., & Goodman, C. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 13233-13238
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094331775
- Cited by
- 180
- References
- 1
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Fambrough, D., Pan, D., Rubin, G. M., & Goodman, C. S. (1996). The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.23.13233
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
