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Heteromultimeric CLC chloride channels with novel properties
Open accessAbstract
The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride → bromide → iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.
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Cited by
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Metadata
- Authors
- Lorenz, C., Pusch, M., & Jentsch, T. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 13362-13366
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014538976
- Cited by
- 247
- References
- 0
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Lorenz, C., Pusch, M., & Jentsch, T. J. (1996). Heteromultimeric CLC chloride channels with novel properties. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.23.13362
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