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ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.
Open accessAbstract
ERK6, a mitogen-activated protein (MAP) kinase-related serine/threonine kinase, is highly expressed in human skeletal muscle and appears to function as a signal transducer during differentiation of myoblasts to myotubes. In transfected 293 cells, activation of the 45-kDa enzyme results in tyrosine-phosphorylated 46- and 56-kDa forms, which phosphorylate myelin basic protein. Overexpression of wild-type ERK6 or the inactive mutant Y185F has no effect on fibroblast and myoblast proliferation, but it enhances or inhibits C2C12 cell differentiation to myotubes, respectively. Our findings suggest ERK6 to be a tissue-specific, differentiation signal-transducing factor that is connected to phosphotyrosine-mediated signaling pathways distinct from those activating other members of the MAP kinase family such as LRK1 and ERK2.
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Cited by
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Wang, Z., Harkins, P. C., Ulevitch, R. J., Han, J., Cobb, M. H., & Goldsmith, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2327 · Cited by 275
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McClung, J. M., Judge, A. R., Powers, S. K., & Yan, Z. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00192.2009 · Cited by 277
Kikuchi, M., Tenneti, L., & Lipton, S. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05037.2000 · Cited by 197
Alsayed, Y., Uddin, S., Mahmud, N., Lekmine, F., Kalvakolanu, D. V., Minucci, S., Bokoch, G., & Platanias, L. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007431200 · Cited by 161
Uddin, S., Ah-Kang, J., Ulaszek, J., Mahmud, D., & Wickrema, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307075101 · Cited by 151
Metadata
- Authors
- Lechner, C., Zahalka, M. A., Giot, J. F., Møller, N. P., & Ullrich, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-04-30
- Volume
- 93
- Issue
- 9
- Pages
- 4355-4359
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003867300
- Cited by
- 327
- References
- 0
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Lechner, C., Zahalka, M. A., Giot, J. F., Møller, N. P., & Ullrich, A. (1996). ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.9.4355
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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