A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells
Open accessAbstract
An Fcα receptor probe of human origin was used to identify novel members of the Ig gene superfamily in mice. P aired I g-like r eceptors, named PIR-A and PIR-B, are predicted from sequence analysis of the cDNAs isolated from a mouse splenic library. Both type I transmembrane proteins possess similar ectodomains with six Ig-like loops, but have different transmembrane and cytoplasmic regions. The predicted PIR-A protein has a short cytoplasmic tail and a charged Arg residue in the transmembrane region that, by analogy with the FcαR relative, suggests the potential for association with an additional transmembrane protein to form a signal transducing unit. In contrast, the PIR-B protein has an uncharged transmembrane region and a long cytoplasmic tail containing four potential immunoreceptor tyrosine-based inhibitory motifs. These features are shared by the related killer inhibitory receptors. PIR-A proteins appear to be highly variable, in that predicted peptide sequences differ for seven randomly selected PIR-A clones, whereas PIR-B cDNA clones are invariant. Southern blot analysis with PIR-B and PIR-A-specific probes suggests only one PIR-B gene and multiple PIR-A genes. The PIR-A and PIR-B genes are expressed in B lymphocytes and myeloid lineage cells, wherein both are expressed simultaneously. The characteristics of the highly-conserved PIR-A and PIR-B genes and their coordinate cellular expression suggest a potential regulatory role in humoral, inflammatory, and allergic responses.
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LILRBs are expressed predominantly on myeloid cells and their murine relatives PirB and gp49B1 differ in expression patterns and ligand specificity.
“LILRBs are expressed predominantly on myeloid cells and their murine relatives—PirB and gp49B121,22—differ in both expression patterns and ligand specificity.”
From Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors (2025) · cites this paper as [21]
The Discussion reports PIR-B expression in B and myeloid lineages and describes gp49B1 expression in mast and NK cells, supporting a difference in expression patterns. But its “Potential Ligands for PIR-A and PIR-B” section says PIR ligand identity was unknown; it does not establish a difference in ligand specificity between PIR-B and gp49B1. The cited paper also does not establish that human LILRBs are predominantly myeloid. (LLM, conf=0.87)
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- Authors
- Kubagawa, H., Burrows, P. D., & Cooper, M. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-05-13
- Volume
- 94
- Issue
- 10
- Pages
- 5261-5266
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24666
- OpenAlex
- W2158449767
- Cited by
- 319
- References
- 52
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01ai034568-04)
- National Institute of Allergy and Infectious Diseases (AI39816, AI34568, R01AI039816, R37AI039816)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- PirB, B cells, myeloid cells, ITIM, killer inhibitory receptors, Fc alpha receptor, signal transduction, gene expression, transmembrane protein structure
- MeSH terms
- Amino Acid Sequence, Animals, B-Lymphocytes, Chromosome Mapping, Chromosomes, Human, Pair 19, DNA, Multigene Family, Genetic Markers, Hematopoietic Stem Cells, Humans, Mice, Inbred BALB C, Molecular Sequence Data, Organ Specificity, Receptors, Immunologic, Spleen, Genetic Variation, Gene Library, Gene Expression, Polymerase Chain Reaction, Sequence Homology, Amino Acid, DNA, Complementary, Mice
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