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Attenuation of G i - and G q -mediated signaling by expression of RGS4 or GAIP in mammalian cells
Open accessAbstract
Protein regulators of G protein signaling (RGS proteins) were discovered as negative regulators of heterotrimeric G protein-mediated signal transduction in yeast and worms. Experiments with purified recombinant proteins in vitro have established that RGS proteins accelerate the GTPase activity of certain G protein α subunits (the reaction responsible for their deactivation); they can also act as effector antagonists. We demonstrate herein that either of two such RGS proteins, RGS4 or GAIP, attenuated signal transduction mediated by endogenous receptors, G proteins, and effectors when stably expressed as tagged proteins in transfected mammalian cells. The pattern of selectivity observed in vivo was similar to that seen in vitro . RGS4 and GAIP both attenuated G i -mediated inhibition of cAMP synthesis. RGS4 was more effective than GAIP in blocking G q -mediated activation of phospholipase Cβ.
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Berridge, M. J., Dawson, R. M. C., Downes, C. P., Heslop, J. P., & Irvine, R. F. (1983) · Biochemical Journal · doi:10.1042/bj2120473 · Cited by 1,954
Cited by
RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors
Xu, X., Zeng, W., Popov, S., Berman, D. M., Davignon, I., Yu, K., Yowe, D., Offermanns, S., Muallem, S., & Wilkie, T. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3549 · Cited by 253
Liu, W., Yuen, E. Y., Allen, P. B., Feng, J., Greengard, P., & Yan, Z. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604560103 · Cited by 79
Lione, A. M., Errico, M., Lin, S. L., & Cowen, D. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750934.x · Cited by 73
Metadata
- Authors
- Huang, C., Hepler, J. R., Gilman, A. G., & Mumby, S. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-06-10
- Volume
- 94
- Issue
- 12
- Pages
- 6159-6163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2034762105
- Cited by
- 173
- References
- 1
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, C., Hepler, J. R., Gilman, A. G., & Mumby, S. M. (1997). Attenuation of G i - and G q -mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.12.6159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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