The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
An intestinal mucin is the target substrate for a baculovirus enhancin
Open accessAbstract
An invertebrate intestinal mucin (IIM) was identified from a lepidopterous insect, Trichoplusia ni . The IIM is a major protein constituent of the peritrophic membrane that facilitates the digestive process, as well as protecting invertebrate digestive tracts from microbial infections. The IIM demonstrated biochemical characteristics similar to vertebrate mucins, but exhibited strong association with the chitin-containing peritrophic membrane matrix. We have demonstrated that a baculovirus enhancin, which is encoded and carried by specific baculoviruses, has mucin-degrading activity both in vitro and in vivo . The in vivo degradation of IIM by enhancin was correlated with the enhancement of baculovirus infections in insects. These findings have shown that viruses have evolved a novel strategy to overcome intestinal mucinous barriers against microorganisms by utilizing a mucin-degrading enzyme.
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Parkhill, J., Wren, B. W., Thomson, N. R., Titball, R. W., Holden, M. T. G., Prentice, M. B., Sebaihia, M., James, K. D., Churcher, C., Mungall, K. L., et al. (2001) · Nature · doi:10.1038/35097083 · Cited by 1,243
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New Insights into Peritrophic Matrix Synthesis, Architecture, and Function
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Drosophila melanogaster as a model for human intestinal infection and pathology
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A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses
Wu, P., Sun, P., Nie, K., Zhu, Y., Shi, M., Xiao, C., Liu, H., Liu, Q., Zhao, T., Chen, X., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.004 · Cited by 267
Self-citation
Metadata
- Authors
- Wang, P., & Granados, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-06-24
- Volume
- 94
- Issue
- 13
- Pages
- 6977-6982
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1995621557
- Cited by
- 274
- References
- 26
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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