The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Origin of Genes
Open accessAbstract
We discuss two tests of the hypothesis that the first genes were assembled from exons. The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will be correlated with compact regions of polypeptide chain. These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes but with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with compact features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by “The Exon Theory of Genes.”
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Gilbert, W. (1986) · Nature · doi:10.1038/319618a0 · Cited by 2,721
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Cited by
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Bird, S., Zou, J., Wang, T., Munday, B., Cunningham, C., & Secombes, C. J. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00028-x · Cited by 266
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Metadata
- Authors
- Gilbert, W., de Souza, S. J., & Long, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-22
- Volume
- 94
- Issue
- 15
- Pages
- 7698-7703
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2021892978
- Cited by
- 235
- References
- 1
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Gilbert, W., de Souza, S. J., & Long, M. (1997). Origin of Genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.15.7698
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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