The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A functionally defined model for the M 2 proton channel of influenza A virus suggests a mechanism for its ion selectivity
Open accessAbstract
The M 2 protein from influenza A virus forms proton-selective channels that are essential to viral function and are the target of the drug amantadine. Cys scanning was used to generate a series of mutants with successive substitutions in the transmembrane segment of the protein, and the mutants were expressed in Xenopus laevis oocytes. The effect of the mutations on reversal potential, ion currents, and amantadine resistance were measured. Fourier analysis revealed a periodicity consistent with a four-stranded coiled coil or helical bundle. A three-dimensional model of this structure suggests a possible mechanism for the proton selectivity of the M 2 channel of influenza virus.
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Citations
Cites
The Fourier transform of a coiled-coil
Crick, F. H. C. (1953) · Acta Crystallographica · doi:10.1107/s0365110x53001952 · Cited by 313
Cited by
Gonzalez, M. E., & Carrasco, L. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00780-4 · Cited by 359
Metadata
- Authors
- Pinto, L. H., Dieckmann, G. R., Gandhi, C. S., Papworth, C. G., Braman, J., Shaughnessy, M. A., Lear, J. D., Lamb, R. A., & DeGrado, W. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-10-14
- Volume
- 94
- Issue
- 21
- Pages
- 11301-11306
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162316896
- Cited by
- 352
- References
- 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Pinto, L. H., Dieckmann, G. R., Gandhi, C. S., Papworth, C. G., Braman, J., Shaughnessy, M. A., Lear, J. D., Lamb, R. A., & DeGrado, W. F. (1997). A functionally defined model for the M 2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.21.11301
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
