The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
Open accessAbstract
The mouse insulin-like growth factor 2 ( Igf2 ) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted transcriptional repression is abolished by null mutations at the linked H19 locus. To clarify the extent to which the Igf2 upstream region contains autonomous imprinting control elements we have performed functional and comparative analyses of the region in the mouse and human. Here we report the existence of multiple, overlapping imprinted (maternally repressed) sense and antisense transcripts that are associated with a tandem repeat in the mouse Igf2 upstream region. Regions flanking the repeat exhibit tissue-specific parental allelic methylation patterns, suggesting the existence of tissue-specific control elements in the upstream region. Studies in H19 null mice indicate that both parental allelic methylation and monoallelic expression of the upstream transcripts depends on an intact H19 gene acting in cis. The homologous region in human IGF2 is structurally conserved, with the significant exception that it does not contain a tandem repeat. Our results support the proposal that tandem repeats act to target methylation to imprinted genetic loci.
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Cites
Bennett, S. T., Lucassen, A. M., Gough, S. C. L., Powell, E. E., Undlien, D. E., Pritchard, L. E., Merriman, M. E., Kawaguchi, Y., Dronsfield, M. J., Pociot, F., et al. (1995) · Nature Genetics · doi:10.1038/ng0395-284 · Cited by 746
Cited by
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
Self-citationEpigenetics: Regulation Through Repression
Wolffe, A. P., & Matzke, M. A. (1999) · Science · doi:10.1126/science.286.5439.481 · Cited by 1,239
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Self-citationMurrell, A., Heeson, S., & Reik, W. (2004) · Nature Genetics · doi:10.1038/ng1402 · Cited by 556
Weinstein, L. S., Yu, S., Warner, D. R., & Liu, J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.5.0439 · Cited by 420
Metadata
- Authors
- Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H., & Reik, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-11-11
- Volume
- 94
- Issue
- 23
- Pages
- 12509-12514
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2108408370
- Cited by
- 252
- References
- 1
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. https://app.cochat.ai/papers/10.1073/pnas.94.23.12509
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- Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H., & Reik, W. (1997). Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.23.12509
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