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Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis
Open accessAbstract
Insecticidal proteins from the soil bacterium Bacillus thuringiensis (Bt) are becoming a cornerstone of ecologically sound pest management. However, if pests quickly adapt, the benefits of environmentally benign Bt toxins in sprays and genetically engineered crops will be short-lived. The diamondback moth ( Plutella xylostella ) is the first insect to evolve resistance to Bt in open-field populations. Here we report that populations from Hawaii and Pennsylvania share a genetic locus at which a recessive mutation associated with reduced toxin binding confers extremely high resistance to four Bt toxins. In contrast, resistance in a population from the Philippines shows multilocus control, a narrower spectrum, and for some Bt toxins, inheritance that is not recessive and not associated with reduced binding. The observed variation in the genetic and biochemical basis of resistance to Bt, which is unlike patterns documented for some synthetic insecticides, profoundly affects the choice of strategies for combating resistance.
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Citations
Cited by
Biochemistry and Genetics of Insect Resistance to Bacillus thuringiensis
Ferré, J., & Van Rie, J. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.47.091201.145234 · Cited by 889
Self-citationField-evolved resistance to Cry1F maize by Spodoptera frugiperda (Lepidoptera: Noctuidae) in Brazil
Farias, J. R., Andow, D. A., Horikoshi, R. J., Sorgatto, R. J., Fresia, P., dos Santos, A. C., & Omoto, C. (2014) · Crop Protection · doi:10.1016/j.cropro.2014.06.019 · Cited by 473
Roush, R. T. (1998) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1998.0330 · Cited by 444
Saxena, D., & Stotzky, G. (2001) · Soil Biology and Biochemistry · doi:10.1016/s0038-0717(01)00027-x · Cited by 384
Field tests on managing resistance to Bt-engineered plants
Shelton, A. M., Tang, J. D., Roush, R. T., Metz, T. D., & Earle, E. D. (2000) · Nature Biotechnology · doi:10.1038/73804 · Cited by 252
Metadata
- Authors
- Tabashnik, B. E., Liu, Y.-B., Malvar, T., Heckel, D. G., Masson, L., Ballester, V., Granero, F., Ménsua, J. L., & Ferré, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-11-25
- Volume
- 94
- Issue
- 24
- Pages
- 12780-12785
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028364985
- Cited by
- 221
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis. https://app.cochat.ai/papers/10.1073/pnas.94.24.12780
- The paper
- Tabashnik, B. E., Liu, Y.-B., Malvar, T., Heckel, D. G., Masson, L., Ballester, V., Granero, F., Ménsua, J. L., & Ferré, J. (1997). Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.24.12780
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
