The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
Open accessAbstract
The proinflammatory cytokine interleukin 1 (IL-1) activates the transcription of many genes encoding acute phase and proinflammatory proteins, a function mediated primarily by the transcription factor NF-κB. An early IL-1 signaling event is the recruitment of the Ser/Thr kinase IRAK to the type I IL-1 receptor (IL-1RI). Here we describe the function of a previously identified IL-1 receptor subunit designated IL-1 receptor accessory protein (IL-1RAcP). IL-1 treatment of cells induces the formation of a complex containing both IL-1RI and IL-1RAcP. IRAK is recruited to this complex through its association with IL-1RAcP. Overexpression of an IL-1RAcP mutant lacking its intracellular domain, the IRAK-binding domain, prevented the recruitment of IRAK to the receptor complex and blocked IL-1-induced NF-κB activation.
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Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
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Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,537
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., & Cao, Z. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,117
Self-citationIL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family
Dinarello, C. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70518-x · Cited by 819
Metadata
- Authors
- Huang, J., Gao, X., Li, S., & Cao, Z.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-11-25
- Volume
- 94
- Issue
- 24
- Pages
- 12829-12832
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989166339
- Cited by
- 226
- References
- 1
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, J., Gao, X., Li, S., & Cao, Z. (1997). Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.24.12829
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