The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
Open accessAbstract
The recently defined DEG/ENaC superfamily of sodium channels includes subunits of the amiloride-sensitive epithelial sodium channel (ENaC) of vertebrate colon, lung, kidney, and tongue, a molluscan FMRFamide-gated channel (FaNaC), and the nematode degenerins, which are suspected mechanosensory channels. We have identified two new members of this superfamily (BNaC1 and BNaC2) in a human brain cDNA library. Phylogenetic analysis indicates they are equally divergent from all other members of the DEG/ENaC superfamily and form a new branch or family. Human BNaC1 maps to 17q11.2-12 and hBNaC2 maps to 12q12. Northern blot and mouse brain in situ hybridizations indicate that both genes are coexpressed in most if not all brain neurons, although their patterns of expression vary slightly, and are expressed early in embryogenesis and throughout life. By analogy to the ENaCs and the degenerins, which form heteromultimeric channels, BNaC1 and BNaC2 may be subunits of the same channel.
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Ziemann, A. E., Schnizler, M. K., Albert, G. W., Severson, M. A., Howard III, M. A., Welsh, M. J., & Wemmie, J. A. (2008) · Nature Neuroscience · doi:10.1038/nn.2132 · Cited by 365
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Presynaptic Release Probability Is Increased in Hippocampal Neurons From ASIC1 Knockout Mice
Cho, J.-H., & Askwith, C. C. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00940.2007 · Cited by 67
Characterization of acid-sensitive ion channels in freshly isolated rat brain neurons
Bolshakov, K. V., Essin, K. V., Buldakova, S. L., Dorofeeva, N. A., Skatchkov, S. N., Eaton, M. J., Tikhonov, D. B., & Magazanik, L. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00582-6 · Cited by 53
Tikhonova, T. B., Nagaeva, E. I., Barygin, O. I., Potapieva, N. N., Bolshakov, K. V., & Tikhonov, D. B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.018 · Cited by 30
Metadata
- Authors
- García-Añoveros, J., Derfler, B., Neville-Golden, J., Hyman, B. T., & Corey, D. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-02-18
- Volume
- 94
- Issue
- 4
- Pages
- 1459-1464
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998564418
- Cited by
- 337
- References
- 39
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
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- García-Añoveros, J., Derfler, B., Neville-Golden, J., Hyman, B. T., & Corey, D. P. (1997). BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.4.1459
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