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Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands
Open accessAbstract
A replication-deficient, recombinant adenovirus encoding human aquaporin-1 (hAQP1), the archetypal water channel, was constructed. This virus, AdhAQP1, directed hAQP1 expression in several epithelial cell lines in vitro . In polarized MDCK cell monolayers, hAQP1 was localized in the apical and basolateral plasma membranes. Fluid movement across monolayers infected by AdhAQP1 in response to an osmotic gradient was ≈4-fold that seen with uninfected monolayers or monolayers infected by a control virus. When AdhAQP1 was administered to rat submandibular glands by retrograde ductal instillation, significant hAQP1 expression was observed by Western blot analysis in crude plasma membranes and by immunohistochemical staining in both acinar and ductal cells. Three or four months after exposure to a single radiation dose (17.5 or 21 Gy, respectively), AdhAQP1 administration to rat submandibular glands led to a two- to threefold increase in salivary secretion compared with secretion from glands administered a control virus. These results suggest that hAQP1 gene transfer may have potential as an unique approach for the treatment of postradiation salivary hypofunction.
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Cited by
The miniature pig: a useful large animal model for dental and orofacial research
Wang, S., Liu, Y., Fang, D., & Shi, S. (2007) · Oral Diseases · doi:10.1111/j.1601-0825.2006.01337.x · Cited by 323
Salivary hypofunction: An update on aetiology, diagnosis and therapeutics
Saleh, J., Figueiredo, M. A. Z., Cherubini, K., & Salum, F. G. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.10.004 · Cited by 237
Metadata
- Authors
- Delporte, C., O’Connell, B. C., He, X., Lancaster, H. E., O’Connell, A. C., Agre, P., & Baum, B. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-04
- Volume
- 94
- Issue
- 7
- Pages
- 3268-3273
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048873879
- Cited by
- 255
- References
- 0
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. https://app.cochat.ai/papers/10.1073/pnas.94.7.3268
- The paper
- Delporte, C., O’Connell, B. C., He, X., Lancaster, H. E., O’Connell, A. C., Agre, P., & Baum, B. J. (1997). Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.7.3268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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