The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
Open accessAbstract
Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (A L cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. Cotreatment of cells with the oxygen radical scavenger dimethyl sulfoxide significantly reduces the mutagenicity of arsenite. Thus, the carcinogenicity of arsenite can be explained at least in part by it being a mutagen that depends on reactive oxygen species for its activity.
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Cites
Zhao, C. Q., Young, M. R., Diwan, B. A., Coogan, T. P., & Waalkes, M. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10907 · Cited by 559
Cited by
Arsenic Exposure and Toxicology: A Historical Perspective
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., & Thomas, D. J. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr184 · Cited by 1,312
Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells
Wu, L.-J., Randers-Pehrson, G., Xu, A., Waldren, C. A., Geard, C. R., Yu, Z., & Hei, T. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4959 · Cited by 444
Self-citationWei, M., Wanibuchi, H., Morimura, K., Iwai, S., Yoshida, K., Endo, G., Nakae, D., & Fukushima, S. (2002) · Carcinogenesis · doi:10.1093/carcin/23.8.1387 · Cited by 222
Arsenic induces oxidative DNA damage in mammalian cells
Kessel, M., Liu, S. X., Xu, A., Santella, R., & Hei, T. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015927406142 · Cited by 135
Self-citationArsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells
Wang, T.-S., Hsu, T.-Y., Chung, C.-H., Wang, A. S. S., Bau, D.-T., & Jan, K.-Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00581-0 · Cited by 121
Metadata
- Authors
- Hei, T. K., Liu, S. X., & Waldren, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-07
- Volume
- 95
- Issue
- 14
- Pages
- 8103-8107
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162088045
- Cited by
- 422
- References
- 1
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Hei, T. K., Liu, S. X., & Waldren, C. (1998). Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.14.8103
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