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Cloning of the Arabidopsis ent -kaurene oxidase gene GA 3
Open accessAbstract
The ga3 mutant of Arabidopsis is a gibberellin-responsive dwarf. We present data showing that the ga3-1 mutant is deficient in ent- kaurene oxidase activity, the first cytochrome P450-mediated step in the gibberellin biosynthetic pathway. By using a combination of conventional map-based cloning and random sequencing we identified a putative cytochrome P450 gene mapping to the same location as GA3 . Relative to the progenitor line, two ga3 mutant alleles contained single base changes generating in-frame stop codons in the predicted amino acid sequence of the P450. A genomic clone spanning the P450 locus complemented the ga3-2 mutant. The deduced GA3 protein defines an additional class of cytochrome P450 enzymes. The GA3 gene was expressed in all tissues examined, RNA abundance being highest in inflorescence tissue.
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Citations
Cited by
Gibberellin metabolism: new insights revealed by the genes
Hedden, P., & Phillips, A. L. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01790-8 · Cited by 1,047
Gibberellin biosynthesis and its regulation
Hedden, P., & Thomas, S. G. (2012) · Biochemical Journal · doi:10.1042/bj20120245 · Cited by 932
Keeling, C. I., & Bohlmann, J. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2006.01716.x · Cited by 721
A Century of Gibberellin Research
Hedden, P., & Sponsel, V. (2015) · Journal of Plant Growth Regulation · doi:10.1007/s00344-015-9546-1 · Cited by 607
Microarray Analysis of Brassinosteroid-Regulated Genes in Arabidopsis
Goda, H., Shimada, Y., Asami, T., Fujioka, S., & Yoshida, S. (2002) · Plant Physiology · doi:10.1104/pp.011254 · Cited by 431
Metadata
- Authors
- Helliwell, C. A., Sheldon, C. C., Olive, M. R., Walker, A. R., Zeevaart, J. A. D., Peacock, W. J., & Dennis, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 9019-9024
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971943943
- Cited by
- 224
- References
- 0
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Helliwell, C. A., Sheldon, C. C., Olive, M. R., Walker, A. R., Zeevaart, J. A. D., Peacock, W. J., & Dennis, E. S. (1998). Cloning of the Arabidopsis ent -kaurene oxidase gene GA 3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.15.9019
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