The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter
Open accessAbstract
ORF slr0798, now designated ziaA , from Synechocystis PCC 6803 encodes a polypeptide with sequence features of heavy metal transporting P-type ATPases. Increased Zn 2+ tolerance and reduced 65 Zn accumulation was observed in Synechococcus PCC 7942, strain R2-PIM8( smt ), containing ziaA and upstream regulatory sequences, compared with control cells. Conversely, reduced Zn 2+ tolerance was observed following disruption of ziaA in Synechocystis PCC 6803, and ziaA -mediated restoration of Zn 2+ tolerance has subsequently been used as a selectable marker for transformation. Nucleotide sequences upstream of ziaA , fused to a promoterless lacZ gene, conferred Zn 2+ -dependent β-galactosidase activity when introduced into R2-PIM8( smt ). The product of ORF sll0792, designated ZiaR, is a Zn 2+ -responsive repressor of ziaA transcription. Reporter gene constructs lacking ziaR conferred elevated Zn 2+ -independent expression from the ziaA operator–promoter in R2-PIM8( smt ). Gel retardation assays detected ZiaR-dependent complexes forming with the zia operator–promoter and ZiaR–DNA binding was enhanced by treatment with a metal-chelator in vitro . Two mutants of ZiaR (C71S/C73S and H116R) bound to, and repressed expression from, the ziaA operator–promoter but were unable to sense Zn 2+ . Metal coordination to His-imidazole and Cys-thiolate ligands at these residues of ZiaR is thus implicated in Zn 2+ -perception by Synechocystis PCC 6803.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
Rensing, C., Mitra, B., & Rosen, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14326 · Cited by 419
Nucifora, G., Chu, L., Misra, T. K., & Silver, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3544 · Cited by 359
Cited by
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489
Toxicity and Bioremediation of Heavy Metals Contaminated Ecosystem from Tannery Wastewater: A Review
Igiri, B. E., Okoduwa, S. I. R., Idoko, G. O., Akabuogu, E. P., Adeyi, A. O., & Ejiogu, I. K. (2018) · Journal of Toxicology · doi:10.1155/2018/2568038 · Cited by 933
Genome of Geobacter sulfurreducens: Metal Reduction in Subsurface Environments
Methé, B. A., Nelson, K. E., Eisen, J. A., Paulsen, I. T., Nelson, W., Heidelberg, J. F., Wu, D., Wu, M., Ward, N., Beanan, M. J., et al. (2003) · Science · doi:10.1126/science.1088727 · Cited by 710
Busenlehner, L. S., Pennella, M. A., & Giedroc, D. P. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00054-8 · Cited by 441
Complete Genomic Structure of the Bloom-forming Toxic Cyanobacterium Microcystis aeruginosa NIES-843
Kaneko, T., Nakajima, N., Okamoto, S., Suzuki, I., Tanabe, Y., Tamaoki, M., Nakamura, Y., Kasai, F., Watanabe, A., Kawashima, K., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm026 · Cited by 284
Metadata
- Authors
- Thelwell, C., Robinson, N. J., & Turner-Cavet, J. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09
- Volume
- 95
- Issue
- 18
- Pages
- 10728-10733
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2155260714
- Cited by
- 177
- References
- 2
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter. https://app.cochat.ai/papers/10.1073/pnas.95.18.10728
- The paper
- Thelwell, C., Robinson, N. J., & Turner-Cavet, J. S. (1998). An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.18.10728
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
