The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Equilibrium distributions of microsatellite repeat length resulting from a balance between slippage events and point mutations
Open accessAbstract
We describe and test a Markov chain model of microsatellite evolution that can explain the different distributions of microsatellite lengths across different organisms and repeat motifs. Two key features of this model are the dependence of mutation rates on microsatellite length and a mutation process that includes both strand slippage and point mutation events. We compute the stationary distribution of allele lengths under this model and use it to fit DNA data for di-, tri-, and tetranucleotide repeats in humans, mice, fruit flies, and yeast. The best fit results lead to slippage rate estimates that are highest in mice, followed by humans, then yeast, and then fruit flies. Within each organism, the estimates are highest in di-, then tri-, and then tetranucleotide repeats. Our estimates are consistent with experimentally determined mutation rates from other studies. The results suggest that the different length distributions among organisms and repeat motifs can be explained by a simple difference in slippage rates and that selective constraints on length need not be imposed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Brook, J. D., McCurrach, M. E., Harley, H. G., Buckler, A. J., Church, D., Aburatani, H., Hunter, K., Stanton, V. P., Thirion, J.-P., Hudson, T., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90154-5 · Cited by 2,777
Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., Richards, S., Verkert, A. J. M. H., Holden, J. J. A., Fenwick, R. G., Warren, S. T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90283-5 · Cited by 2,080
A second-generation linkage map of the human genome
Weissenbach, J., Gyapay, G., Dib, C., Vignal, A., Morissette, J., Millasseau, P., Vaysseix, G., & Lathrop, M. (1992) · Nature · doi:10.1038/359794a0 · Cited by 1,685
Mutation of human short tandem repeats
Weber, J. L., & Wong, C. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.8.1123 · Cited by 1,555
Mutational processes of simple-sequence repeat loci in human populations.
Di Rienzo, A., Peterson, A. C., Garza, J. C., Valdes, A. M., Slatkin, M., & Freimer, N. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3166 · Cited by 1,535
Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups
Edwards, A., Hammond, H. A., Jin, L., Caskey, C. T., & Chakraborty, R. (1992) · Genomics · doi:10.1016/0888-7543(92)90371-x · Cited by 1,426
Informativeness of human (dC-dA)n · (dG-dT)n polymorphisms
Weber, J. L. (1990) · Genomics · doi:10.1016/0888-7543(90)90195-z · Cited by 1,345
Ohta, T., & Kimura, M. (1973) · Genetical Research · doi:10.1017/s0016672300012994 · Cited by 1,176
A genetic map of the mouse suitable for typing intraspecific crosses.
Dietrich, W., Katz, H., Lincoln, S. E., Shin, H. S., Friedman, J., Dracopoli, N. C., & Lander, E. S. (1992) · Genetics · doi:10.1093/genetics/131.2.423 · Cited by 1,089
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Greig, C., Jacobson, D. P., & Banks, M. A. (2003) · Molecular Ecology Notes · doi:10.1046/j.1471-8286.2003.00455.x · Cited by 1,610
Evolutionary dynamics of microsatellite DNA
Schlötterer, C. (2000) · Chromosoma · doi:10.1007/s004120000089 · Cited by 818
Microsatellite mutations in the germline:
Ellegren, H. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02139-9 · Cited by 676
Metadata
- Authors
- Kruglyak, S., Durrett, R. T., Schug, M. D., & Aquadro, C. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-09
- Volume
- 95
- Issue
- 18
- Pages
- 10774-10778
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970114035
- Cited by
- 437
- References
- 30
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Equilibrium distributions of microsatellite repeat length resulting from a balance between slippage events and point mutations. https://app.cochat.ai/papers/10.1073/pnas.95.18.10774
- The paper
- Kruglyak, S., Durrett, R. T., Schug, M. D., & Aquadro, C. F. (1998). Equilibrium distributions of microsatellite repeat length resulting from a balance between slippage events and point mutations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.18.10774
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
