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A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G β5 subunits
Open accessAbstract
Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the α subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein γ subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different G β subunits reveals specific interaction between RGS11 and G β5 . The expression of mRNA for RGS11 and G β5 in human tissues overlaps. The G β5 /RGS11 heterodimer acts as a GAP on G αo , apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for G α proteins and form complexes with specific G β subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.
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Cited by
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Chen, C.-K., Burns, M. E., He, W., Wensel, T. G., Baylor, D. A., & Simon, M. I. (2000) · Nature · doi:10.1038/35000601 · Cited by 527
Regulators of G-Protein signalling as new central nervous system drug targets
Neubig, R. R., & Siderovski, D. P. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd747 · Cited by 403
Self-citationRegulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins
Magalhaes, A. C., Dunn, H., & Ferguson, S. S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01552.x · Cited by 353
Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels
Nguyen, H., Glaaser, I. W., & Slesinger, P. A. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1386645 · Cited by 29
Metadata
- Authors
- Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S.-F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G., & Siderovski, D. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-10-27
- Volume
- 95
- Issue
- 22
- Pages
- 13307-13312
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016923687
- Cited by
- 258
- References
- 0
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G β5 subunits. https://app.cochat.ai/papers/10.1073/pnas.95.22.13307
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- Snow, B. E., Krumins, A. M., Brothers, G. M., Lee, S.-F., Wall, M. A., Chung, S., Mangion, J., Arya, S., Gilman, A. G., & Siderovski, D. P. (1998). A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G β5 subunits. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.22.13307
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