The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Open accessAbstract
To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergic receptor subtypes. In the present report, we demonstrate that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces). 5-HT1A knockout mice also exhibited a decreased immobility in the forced swim test, an effect commonly associated with antidepressant treatment. Although 5-HT1A receptors are involved in controlling the activity of serotonergic neurons, 5-HT1A knockout mice had normal levels of 5-HT and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-HT1B autoreceptors. Heterozygote 5-HT1A mutants expressed approximately one-half of wild-type receptor density and displayed intermediate phenotypes in most behavioral tests. These results demonstrate that 5-HT1A receptors are involved in the modulation of exploratory and fear-related behaviors and suggest that reductions in 5-HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.
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Metadata
- Authors
- Ramboz, S., Oosting, R., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M., Mann, J. J., Brunner, D., & Hen, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-11-24
- Volume
- 95
- Issue
- 24
- Pages
- 14476-14481
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987299915
- Cited by
- 814
- References
- 22
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Serotonin receptor 1A knockout: An animal model of anxiety-related disorder. https://app.cochat.ai/papers/10.1073/pnas.95.24.14476
- The paper
- Ramboz, S., Oosting, R., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M., Mann, J. J., Brunner, D., & Hen, R. (1998). Serotonin receptor 1A knockout: An animal model of anxiety-related disorder. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.24.14476
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
