The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
Open accessAbstract
Antigen presentation by major histocompatibility complex (MHC) class II molecules requires the participation of different proteases in the endocytic route to degrade endocytosed antigens as well as the MHC class II-associated invariant chain (Ii). Thus far, only the cysteine protease cathepsin (Cat) S appears essential for complete destruction of Ii. The enzymes involved in degradation of the antigens themselves remain to be identified. Degradation of antigens in vitro and experiments using protease inhibitors have suggested that Cat B and Cat D, two major aspartyl and cysteine proteases, respectively, are involved in antigen degradation. We have analyzed the antigen-presenting properties of cells derived from mice deficient in either Cat B or Cat D. Although the absence of these proteases provoked a modest shift in the efficiency of presentation of some antigenic determinants, the overall capacity of Cat B−/−or Cat D−/−antigen-presenting cells was unaffected. Degradation of Ii proceeded normally in Cat B−/−splenocytes, as it did in Cat D−/−cells. We conclude that neither Cat B nor Cat D are essential for MHC class II-mediated antigen presentation.
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Cites
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Self-citationThe structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3
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Cited by
Lysosomal cysteine proteases: more than scavengers
Turk, B., Turk, D., & Turk, V. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00263-0 · Cited by 844
NEW EMBO MEMBERS' REVIEW: Lysosomal cysteine proteases: facts and opportunities
Turk, V. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4629 · Cited by 756
Guicciardi, M. E., Deussing, J., Miyoshi, H., Bronk, S. F., Svingen, P. A., Peters, C., Kaufmann, S. H., & Gores, G. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9914 · Cited by 710
Self-citationFoghsgaard, L., Wissing, D., Mauch, D., Lademann, U., Bastholm, L., Boes, M., Elling, F., Leist, M., & Jäättelä, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.999 · Cited by 629
Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
Boya, P., Andreau, K., Poncet, D., Zamzami, N., Perfettini, J.-L., Metivier, D., Ojcius, D. M., Jäättelä, M., & Kroemer, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021952 · Cited by 483
Metadata
- Authors
- Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H. L., & Villadangos, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-04-14
- Volume
- 95
- Issue
- 8
- Pages
- 4516-4521
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1963913202
- Cited by
- 266
- References
- 39
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. https://app.cochat.ai/papers/10.1073/pnas.95.8.4516
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- Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H. L., & Villadangos, J. A. (1998). Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.8.4516
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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