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High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods
Open accessAbstract
RGS9 is a member of the RGS family of GTPase accelerating proteins (GAPs) for heterotrimeric G proteins. We have explored its contribution to GTPase acceleration in mammalian rod and cone photoreceptors. When RGS9 was specifically removed from detergent extracts of rod outer segments by immunodepletion, the extracts lost nearly all of their GAP activity stimulatable by the inhibitory subunit of cGMP phosphodiesterase. Immunolocalization using monoclonal antibodies and confocal microscopy revealed that RGS9 is present in cones at significantly higher levels than in rods. Thus, RGS9 is the predominant source of GAP activity in rod outer segments, and RGS9 concentration emerges as a potentially important determinant of the faster response kinetics and lower sensitivity of mammalian cones, as compared with rods.
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Citations
Cites
Visual transduction in cones of the monkey Macaca fascicularis.
Schnapf, J. L., Nunn, B. J., Meister, M., & Baylor, D. A. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018193 · Cited by 478
Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina
Polans, A., Baehr, W., & Palczewski, K. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10059-x · Cited by 288
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The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1
Chen, C.-K., Burns, M. E., He, W., Wensel, T. G., Baylor, D. A., & Simon, M. I. (2000) · Nature · doi:10.1038/35000601 · Cited by 527
Self-citationRhodopsin phosphorylation: 30 years later
Maeda, T. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00017-x · Cited by 152
Metadata
- Authors
- Cowan, C. W., Fariss, R. N., Sokal, I., Palczewski, K., & Wensel, T. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-04-28
- Volume
- 95
- Issue
- 9
- Pages
- 5351-5356
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974004650
- Cited by
- 184
- References
- 2
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Cowan, C. W., Fariss, R. N., Sokal, I., Palczewski, K., & Wensel, T. G. (1998). High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.9.5351
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
