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A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2
Open accessAbstract
Bipolar disorder is a severe mental illness characterized by mood swings of elation and depression. Family, twin, and adoption studies suggest a complex genetic etiology that may involve multiple susceptibility genes and an environmental component. To identify chromosomal loci contributing to vulnerability, we have conducted a genome-wide scan on ≈396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers. Multipoint nonparametric analysis detected the strongest evidence for linkage at 13q32 with a maximal logarithm of odds (lod) score of 3.5 ( P = 0.000028) under a phenotype model that included bipolar I, bipolar II with major depression, schizoaffective disorder, and recurrent unipolar disorder. Suggestive linkage was found on 1q31-q32 (lod = 2.67; P = 0.00022) and 18p11.2 (lod = 2.32; P = 0.00054). Recent reports have linked schizophrenia to 13q32 and 18p11.2. Our genome scan identified other interesting regions, 7q31 (lod = 2.08; P = 0.00099) and 22q11-q13 (lod = 2.1; P = 0.00094), and also confirmed reported linkages on 4p16, 12q23-q24, and 21q22. By comprehensive screening of the entire genome, we detected unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar disorder and schizophrenia.
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Cited by
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254
Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia
Badner, J. A., & Gershon, E. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001012 · Cited by 811
Self-citationThe DISC locus in psychiatric illness
Chubb, J. E., Bradshaw, N. J., Soares, D. C., Porteous, D. J., & Millar, J. K. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002106 · Cited by 542
Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318
McQueen, M. B., Devlin, B., Faraone, S. V., Nimgaonkar, V. L., Sklar, P., Smoller, J. W., Abou Jamra, R., Albus, M., Bacanu, S.-A., Baron, M., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/491603 · Cited by 245
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Metadata
- Authors
- Detera-Wadleigh, S. D., Badner, J. A., Berrettini, W. H., Yoshikawa, T., Goldin, L. R., Turner, G., Rollins, D. Y., Moses, T., Sanders, A. R., Karkera, J. D., Esterling, L. E., Zeng, J., Ferraro, T. N., Guroff, J. J., Kazuba, D., Maxwell, M. E., Nurnberger, J. I., & Gershon, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-11
- Volume
- 96
- Issue
- 10
- Pages
- 5604-5609
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117703098
- Cited by
- 390
- References
- 0
- FWCI
- 23.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. https://app.cochat.ai/papers/10.1073/pnas.96.10.5604
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- Detera-Wadleigh, S. D., Badner, J. A., Berrettini, W. H., Yoshikawa, T., Goldin, L. R., Turner, G., Rollins, D. Y., Moses, T., Sanders, A. R., Karkera, J. D., Esterling, L. E., Zeng, J., Ferraro, T. N., Guroff, J. J., Kazuba, D., Maxwell, M. E., Nurnberger, J. I., & Gershon, E. S. (1999). A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.10.5604
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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