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A new pathway for the secretion of virulence factors by bacteria: The flagellar export apparatus functions as a protein-secretion system
Open accessAbstract
Biogenesis of the flagellum, a motive organelle of many bacterial species, is best understood for members of the Enterobacteriaceae . The flagellum is a heterooligomeric structure that protrudes from the surface of the cell. Its assembly initially involves the synthesis of a dedicated protein export apparatus that subsequently transports other flagellar proteins by a type III mechanism from the cytoplasm to the outer surface of the cell, where oligomerization occurs. In this study, the flagellum export apparatus was shown to function also as a secretion system for the transport of several extracellular proteins in the pathogenic bacterium Yersinia enterocolitica . One of the proteins exported by the flagellar secretion system was the virulence-associated phospholipase, YplA. These results suggest type III protein secretion by the flagellar system may be a general mechanism for the transport of proteins that influence bacterial–host interactions.
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Citations
Cited by
The Role of the Bacterial Flagellum in Adhesion and Virulence
Haiko, J., & Westerlund-Wikström, B. (2013) · Biology · doi:10.3390/biology2041242 · Cited by 589
The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells
Girón, J. A., Torres, A. G., Freer, E., & Kaper, J. B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02899.x · Cited by 363
Regulation cascade of flagellar expression in Gram-negative bacteria
Soutourina, O. A., & Bertin, P. N. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00064-0 · Cited by 363
(2005) · PubMed · Cited by 246
Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia
Beeby, M., Ferreira, J. L., Tripp, P., Albers, S.-V., & Mitchell, D. R. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa006 · Cited by 110
Metadata
- Authors
- Young, G. M., Schmiel, D. H., & Miller, V. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-05-25
- Volume
- 96
- Issue
- 11
- Pages
- 6456-6461
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052212787
- Cited by
- 402
- References
- 0
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A new pathway for the secretion of virulence factors by bacteria: The flagellar export apparatus functions as a protein-secretion system. https://app.cochat.ai/papers/10.1073/pnas.96.11.6456
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- Young, G. M., Schmiel, D. H., & Miller, V. L. (1999). A new pathway for the secretion of virulence factors by bacteria: The flagellar export apparatus functions as a protein-secretion system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.11.6456
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
