Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

Samad, Fahumiya; Uysal, K. Teoman; Wiesbrock, Sarah M.; Pandey, Manjula; Hotamisligil, Gökhan S.; Loskutoff, David J.

doi:10.1073/pnas.96.12.6902

Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminogen activator inhibitor 1 (PAI-1) and transforming growth factor β (TGF-β). Although these changes may increase the risk for accelerated atheros…