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A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem
Open accessAbstract
Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron , a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a molecular sensor of l -fucose availability. FucR coordinates expression of an operon encoding enzymes in the l -fucose metabolic pathway with expression of another locus that regulates production of fucosylated glycans in intestinal enterocytes. Genetic and biochemical studies indicate that FucR does this by using fucose as an inducer at one locus and as a corepressor at the other locus. Coordinating this commensal’s immediate nutritional requirements with production of a host-derived energy source is consistent with its need to enter and persist within a competitive ecosystem.
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Citations
Cited by
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Self-citationGut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
“In Bacteroides thetaiotaomicron, the presence of fucose as a growth substrate not only stimulates expression of genes involved in fucose metabolism, but intracellular fucose levels are also critical in activating a signalling mechanism to the host, increasing synthesis of fucosylated glycans [23] and thus ensuring a c…”
BackgroundCommensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Self-citationMicrobial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331
Metadata
- Authors
- Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T., & Gordon, J. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-08-17
- Volume
- 96
- Issue
- 17
- Pages
- 9833-9838
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060144673
- Cited by
- 500
- References
- 0
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1999). A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.17.9833
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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