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Nonstatistical binding of a protein to clustered carbohydrates
Open accessAbstract
Carbohydrate-derivatized self-assembled monolayers (SAMs) are used as a model system to address issues involving cell-surface carbohydrate–protein interactions. Here we examine the influence of carbohydrate surface density on protein-binding avidity. We show that the binding selectivity of Bauhinia purpurea lectin switches from one carbohydrate ligand to another as the surface density of the carbohydrate ligands increases from values of χ sugar ≈ 0.1–1.0. Polyvalent binding is possible at all surface densities investigated; hence, the switch in selectivity is not due simply to the achievement of a critical density that permits polyvalent contacts. Instead, secondary interactions at high surface densities promote a switch in carbohydrate-binding selectivity. These findings may have implications for how changes in the composition and the density of cell-surface carbohydrates influence biological recognition processes and regulatory pathways.
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Cited by
Synthesis of Sugar Arrays in Microtiter Plate
Fazio, F., Bryan, M. C., Blixt, O., Paulson, J. C., & Wong, C.-H. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020887u · Cited by 489
de la Fuente, J. M., & Penadés, S. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.12.001 · Cited by 269
Design and synthesis of glycodendrimers
Turnbull, W. B., & Stoddart, J. F. (2002) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(01)00062-9 · Cited by 262
A Model for Describing the Thermodynamics of Multivalent Host−Guest Interactions at Interfaces
Huskens, J., Mulder, A., Auletta, T., Nijhuis, C. A., Ludden, M. J. W., & Reinhoudt, D. N. (2004) · Journal of the American Chemical Society · doi:10.1021/ja049085k · Cited by 257
Xiao, Q., Zhang, S., Wang, Z., Sherman, S. E., Moussodia, R.-O., Peterca, M., Muncan, A., Williams, D. R., Hammer, D. A., Vértesy, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524976113 · Cited by 100
Metadata
- Authors
- Horan, N., Yan, L., Isobe, H., Whitesides, G. M., & Kahne, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-10-12
- Volume
- 96
- Issue
- 21
- Pages
- 11782-11786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2148444220
- Cited by
- 203
- References
- 0
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Horan, N., Yan, L., Isobe, H., Whitesides, G. M., & Kahne, D. (1999). Nonstatistical binding of a protein to clustered carbohydrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.21.11782
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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