The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
Open accessAbstract
Plague, one of the most devastating diseases of human history, is caused by Yersinia pestis . In this study, we analyzed the population genetic structure of Y. pestis and the two other pathogenic Yersinia species, Y. pseudotuberculosis and Y. enterocolitica . Fragments of five housekeeping genes and a gene involved in the synthesis of lipopolysaccharide were sequenced from 36 strains representing the global diversity of Y. pestis and from 12–13 strains from each of the other species. No sequence diversity was found in any Y. pestis gene, and these alleles were identical or nearly identical to alleles from Y. pseudotuberculosis . Thus, Y. pestis is a clone that evolved from Y. pseudotuberculosis 1,500–20,000 years ago, shortly before the first known pandemics of human plague. Three biovars (Antiqua, Medievalis, and Orientalis) have been distinguished by microbiologists within the Y. pestis clone. These biovars form distinct branches of a phylogenetic tree based on restriction fragment length polymorphisms of the locations of the IS 100 insertion element. These data are consistent with previous inferences that Antiqua caused a plague pandemic in the sixth century, Medievalis caused the Black Death and subsequent epidemics during the second pandemic wave, and Orientalis caused the current plague pandemic.
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“At the same time, Yersinia pestis enables switching hosts with just a few horizontally acquired traits.42”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [42]
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Cites
Evolution of Protein Molecules
JUKES, T. H., & CANTOR, C. R. (1969) · Mammalian Protein Metabolism · doi:10.1016/b978-1-4832-3211-9.50009-7 · Cited by 11,032
Maiden, M. C. J., Bygraves, J. A., Feil, E. J., Morelli, G., Russell, J. E., Urwin, R., Zhang, Q., Zhou, J., Zurth, K., Caugant, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3140 · Cited by 3,891
Self-citationvan Embden, J. D., Cave, M. D., Crawford, J. T., Dale, J. W., Eisenach, K. D., Gicquel, B., Hermans, P. W. M., Martı́n, C., McAdam, R. A., & Shinnick, T. M. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.2.406-409.1993 · Cited by 2,341
Rozas, J., & Rozas, R. (1999) · Bioinformatics · doi:10.1093/bioinformatics/15.2.174 · Cited by 1,950
Yersinia pestis--etiologic agent of plague
Perry, R. D., & Fetherston, J. D. (1997) · Clinical Microbiology Reviews · doi:10.1128/cmr.10.1.35 · Cited by 1,861
Escherichia coli and Salmonella.
Neidhart, F. C. (1996) · Cited by 1,577
Enright, M. C., & Spratt, B. G. (1998) · Microbiology · doi:10.1099/00221287-144-11-3049 · Cited by 1,078
Sreevatsan, S., Pan, X., Stockbauer, K. E., Connell, N. D., Kreiswirth, B. N., Whittam, T. S., & Musser, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9869 · Cited by 1,035
Evolution in bacteria: Evidence for a universal substitution rate in cellular genomes
Ochman, H., & Wilson, A. C. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02111283 · Cited by 780
Free recombination within Helicobacter pylori
Suerbaum, S., Smith, J. M., Bapumia, K., Morelli, G., Smith, N. H., Kunstmann, E., Dyrek, I., & Achtman, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12619 · Cited by 602
Self-citation
Research works printed but not linked: 6
- A Yersin Ann Inst Pasteur 2, 428–430 (1894).
- R Devignat Bull W H O 4, 247–263 (1951).
- T K A Siongok, A M Njagi, S Masaba East African Med J 54, 694–699 (1977).
- C E Yunker, M N Kaiser, H Hoogstraal, A E A Salah J Egypt Public Health Assoc 34, 43–55 (1959).
- V M Lipaev, O A Antip’eva, Z T Al’shevskaya, V M Chipanina, O L Kozlovskaya, V I Chipanin Zool Zhur 49, 1386–1390 (1970).
- G Blanc, M Balthazard C R Soc Biol Paris 138, 811–812 (1944).
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Feil, E. J., Li, B. C., Aanensen, D. M., Hanage, W. P., & Spratt, B. G. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.5.1518-1530.2004 · Cited by 1,861
Report of the ad hoc committee for the re-evaluation of the species definition in bacteriology.
Stackebrandt, E. S., Frederiksen, W. C., Garrity, G. M., Grimont, P. A. D., Kämpfer, P., Maiden, M. C. J., Nesme, X., Rossello-Mora, R. A., Swings, J., Trüper, H. G., et al. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-3-1043 · Cited by 1,551
Pourcel, C., Salvignol, G., & Vergnaud, G. (2005) · Microbiology · doi:10.1099/mic.0.27437-0 · Cited by 1,201
Genome sequence of Yersinia pestis, the causative agent of plague
Parkhill, J., Wren, B. W., Thomson, N. R., Titball, R. W., Holden, M. T. G., Prentice, M. B., Sebaihia, M., James, K., Churcher, C. M., Mungall, K. L., et al. (2001) · Nature · doi:10.1038/35097083 · Cited by 1,244
LPS, TLR4 and infectious disease diversity
Miller, S., Ernst, R. K., & Bader, M. W. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1068 · Cited by 1,059
Metadata
- Authors
- Achtman, M., Zurth, K., Morelli, G., Torrea, G., Guiyoule, A., & Carniel, E.
- Affiliations
- Institut Pasteur (FR)
- Max-Planck-Institut für molekulare Genetik, Ihnestrasse 73, 14195 Berlin, Germany; and Unité de Bactériologie Moléculaire et Médicale, Laboratoire des Yersinia, Institut Pasteur, 75724 Paris Cedex 15, France
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-11-23
- Volume
- 96
- Issue
- 24
- Pages
- 14043-14048
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC24187
- OpenAlex
- W2111205680
- Cited by
- 1,126
- References
- 43
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 38 · 2023: 33 · 2022: 22 · 2021: 20 · 2020: 31 · 2019: 36 · 2018: 29 · 2017: 29 · 2016: 44 · 2015: 42 · 2014: 63 · 2013: 47 · 2012: 61
- FWCI
- 15.20
- Type
- journal article
- Language
- en
- Update notices
- correction (2000-07-05)
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Yersinia bacterium, plague, ectoparasites research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- Yersinia pestis, plague, Yersinia pseudotuberculosis, Yersinia enterocolitica, bacterial clonality, population structure, housekeeping genes, lipopolysaccharide biosynthesis, biovars, phylogenetic analysis, Black Death, plague pandemics, bacterial evolution
- MeSH terms
- Alleles, Base Sequence, DNA, Bacterial, Genes, Bacterial, Humans, Molecular Sequence Data, Plague, Yersinia pestis, Yersinia pseudotuberculosis, Evolution, Molecular
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