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Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1

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Fleming, Robert E., Migas, Mary C., Zhou, XiaoYan, Jiang, Jinxing, Britton, Robert S., Brunt, Elizabeth M., Tomatsu, Shunji, Waheed, Abdul, Bacon, Bruce R., Sly, William S.·1999·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.96.6.3143PMC PMC15909

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Abstract

Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by tissue iron deposition secondary to excessive dietary iron absorption. We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal crypt cells, leading to up-regulation of transporters for dietary iron. Here, we tested the hypothesis that HFE −/− mice have increased duodenal expression of the divalent metal transporter (DMT1). By 4 weeks of age, the HFE −/− mice demonstrated iron loading when compared with HFE +/+ littermates, with elevated transferrin saturations (68.4% vs. 49.8%) and elevated liver iron concentrations (985 μg/g vs. 381 μg/g). By using Northern blot analyses, we quantitated duodenal expression of both classes of DMT1 transcripts: one containing an iron responsive element (IRE), called DMT1(IRE), and one containing no IRE, called DMT1(non-IRE). The positive control for DMT1 up-regulation was a murine model of dietary iron deficiency that demonstrated greatly increased levels of duodenal DMT1(IRE) mRNA. HFE −/− mice also demonstrated an increase in duodenal DMT1(IRE) mRNA (average 7.7-fold), despite their elevated transferrin saturation and hepatic iron content. Duodenal expression of DMT1(non-IRE) was not increased, nor was hepatic expression of DMT1 increased. These data support the model for HH in which HFE mutations lead to inappropriately low crypt cell iron, with resultant stabilization of DMT1(IRE) mRNA, up-regulation of DMT1, and increased absorption of dietary iron.

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Self-citation
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
Fort, P., Marty, L., Piechaczyk, M., Sabrouty, S. R.-E., Dani, C., Jeanteur, P., & Blanchard, J. (1985) · Nucleic Acids Research · doi:10.1093/nar/13.5.1431 · Cited by 2,072
Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport
Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebrón, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., & Schatzman, R. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1472 · Cited by 827
Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor
Lebrón, J. A., Bennett, M. J., Vaughn, D. E., Chirino, A. J., Snow, P. M., Mintier, G. A., Feder, J. N., & Björkman, P. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81151-4 · Cited by 639
Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood Donors
Edwards, C. Q., Griffen, L. M., Goldgar, D. E., Drummond, C., Skolnick, M. H., & Kushner, J. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805263182103 · Cited by 628
HFE gene knockout produces mouse model of hereditary hemochromatosis
Zhou, X. Y., Tomatsu, S., Fleming, R. E., Parkkila, S., Waheed, A., Jiang, J., Fei, Y., Brunt, E. M., Ruddy, D. A., Prass, C. E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2492 · Cited by 519
Self-citation
Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
Parkkila, S., Waheed, A., Britton, R. S., Bacon, B. R., Zhou, X. Y., Tomatsu, S., Fleming, R. E., & Sly, W. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13198 · Cited by 336
Self-citation
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Lee, P. L., Gelbart, T., West, C., Halloran, C., & Beutler, E. (1998) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1998.0186 · Cited by 318

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Show all 46 references

Research works printed but not linked: 7

P M Smith, B E Godfrey, R Williams Clin Sci 37, 519–531 (1969).
G D McLaren, M H Nathanson, A Jacobs, D Trevett, W Thomson J Lab Clin Med 117, 390–401 (1991).
J D Torrance, T H Bothwell Methods Haematol 1, 90–115 (1980).
J Fielding Methods Haematol 1, 15–43 (1980).
P R Flanagan, A Hajdu, P C Adams Hepatology 22, 828–832 (1995).
J C Barton, M A Patton, C Q Edwards, L M Griffen, J P Kushner, R G Meeks, R W Leggett J Lab Clin Med 124, 193–198 (1994).
Saarnio J. Parkkila S. Parkkila A.-K. Waheed A. Karttunen T. & Sly W. S. (1999) J. Histochem. Cytochem . in press.

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Authors: Fleming, R. E., Migas, M. C., Zhou, X., Jiang, J., Britton, R. S., Brunt, E. M., Tomatsu, S., Waheed, A., Bacon, B. R., & Sly, W. S.
Affiliations: Saint Louis University (US)
Department of Pediatrics, Edward A. Doisy Department of Biochemistry and Molecular Biology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, and Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO 63104
ORCID: Fleming, Robert E.
Brunt, Elizabeth M.
Tomatsu, Shunji
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1999-03-16
Volume: 96
Issue: 6
Pages: 3143-3148
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.96.6.3143
PMC: PMC15909
OpenAlex: W2089161230
Cited by: 269
References: 46
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 5
FWCI: 21.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (GM34182)
National Institute of General Medical Sciences (GM35182, R01GM034182)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 53405, R01DK041816, DK 41816, R01DK053405)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: hereditary hemochromatosis, HFE gene, DMT1, iron absorption, iron-responsive element, transferrin receptor, dietary iron deficiency, iron overload, liver iron concentration, transferrin saturation, Hfe knockout mice
MeSH terms: Solute Carrier Family 11, Member 2, Animals, Carrier Proteins, Duodenum, Hemochromatosis, Iron, Mutation, Cation Transport Proteins, Iron-Binding Proteins, Mice

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Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1

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