The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase
Open accessAbstract
Phosphorylation is thought to be an essential first step in the prompt deactivation of photoexcited rhodopsin.In vitro, the phosphorylation can be catalyzed either by rhodopsin kinase (RK) or by protein kinase C (PKC). To investigate the specific role of RK, we inactivated both alleles of the RK gene in mice. This eliminated the light-dependent phosphorylation of rhodopsin and caused the single-photon response to become larger and longer lasting than normal. These results demonstrate that RK is required for normal rhodopsin deactivation. When the photon responses of RK−/− rods did finally turn off, they did so abruptly and stochastically, revealing a first-order backup mechanism for rhodopsin deactivation. The rod outer segments of RK−/− mice raised in 12-hr cyclic illumination were 50% shorter than those of normal (RK+/+) rods or rods from RK−/− mice raised in constant darkness. One day of constant light caused the rods in the RK−/− mouse retina to undergo apoptotic degeneration. Mice lacking RK provide a valuable model for the study of Oguchi disease, a human RK deficiency that causes congenital stationary night blindness.
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Citations
Cites
Responses of retinal rods to single photons.
Baylor, D. A., Lamb, T. D., & Yau, K. W. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012716 · Cited by 992
Self-citation
Cited by
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,701
Dark adaptation and the retinoid cycle of vision
Lamb, T. D., & Pugh, E. N. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.03.001 · Cited by 725
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1
Chen, C.-K., Burns, M. E., He, W., Wensel, T. G., Baylor, D. A., & Simon, M. I. (2000) · Nature · doi:10.1038/35000601 · Cited by 527
Self-citationPugh, E. N., & Lamb, T. D. (2000) · Handbook of Biological Physics · doi:10.1016/s1383-8121(00)80008-1 · Cited by 324
Boulton, M., Różanowska, M., & Różanowski, B. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00227-5 · Cited by 322
Metadata
- Authors
- Chen, C.-K., Burns, M. E., Spencer, M., Niemi, G. A., Chen, J., Hurley, J. B., Baylor, D. A., & Simon, M. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-03-30
- Volume
- 96
- Issue
- 7
- Pages
- 3718-3722
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999179844
- Cited by
- 352
- References
- 1
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, C.-K., Burns, M. E., Spencer, M., Niemi, G. A., Chen, J., Hurley, J. B., Baylor, D. A., & Simon, M. I. (1999). Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.7.3718
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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