The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Double-stranded RNA specifically disrupts gene expression during planarian regeneration
Open accessAbstract
Metazoan regeneration is one of the least understood fundamental problems of biology. The lack of progress in understanding this phenomenon at the molecular level has been due to the poor regenerative abilities of the genetic organisms used for developmental studies, as well as the difficulties encountered with molecular and genetic manipulations of the commonly studied vertebrate models (the urodele amphibians). Here, we demonstrate that introduction of double-stranded RNA selectively abrogates gene function in planarians, a classic model of regeneration. The ability to eliminate gene function in a regenerating organism such as the planarian overcomes previous experimental limitations and opens the study of animal regeneration to unprecedented levels of molecular detail.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Cited by
Wang, Z., Morris, J. C., Drew, M. E., & Englund, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m008405200 · Cited by 517
Bridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Fincher, C. T., Wurtzel, O., de Hoog, T., Kravarik, K. M., & Reddien, P. W. (2018) · Science · doi:10.1126/science.aaq1736 · Cited by 436
Smed- β catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration
Petersen, C. P., & Reddien, P. W. (2008) · Science · doi:10.1126/science.1149943 · Cited by 364
Cebrià, F., & Newmark, P. A. (2005) · Development · doi:10.1242/dev.01941 · Cited by 286
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Metadata
- Authors
- Sánchez Alvarado, A., & Newmark, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5049-5054
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072572526
- Cited by
- 535
- References
- 1
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Sánchez Alvarado, A., & Newmark, P. A. (1999). Double-stranded RNA specifically disrupts gene expression during planarian regeneration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.9.5049
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
