The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-Å resolution
Open accessAbstract
In this paper, we describe the structure of chitinase B from Serratia marcescens , which consists of a catalytic domain with a TIM-barrel fold and a 49-residue C-terminal chitin-binding domain. This chitinase is the first structure of a bacterial exochitinase, and it represents one of only a few examples of a glycosyl hydrolase structure having interacting catalytic and substrate-binding domains. The chitin-binding domain has exposed aromatic residues that contribute to a 55-Å long continuous aromatic stretch extending into the active site. Binding of chitin oligomers is blocked beyond the −3 subsite, which explains why the enzyme has chitotriosidase activity and degrades the chitin chain from the nonreducing end. Comparison of the chitinase B structure with that of chitinase A explains why these enzymes act synergistically in the degradation of chitin.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Protein Structure Comparison by Alignment of Distance Matrices
Holm, L., & Sander, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1489 · Cited by 3,984
Cited by
Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
Protein Function Prediction Using Local 3D Templates
Laskowski, R. A., Watson, J. D., & Thornton, J. M. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.067 · Cited by 213
Role of Chitotriosidase (Chitinase 1) Under Normal and Disease Conditions
Kanneganti, M. (2012) · Journal of Epithelial Biology and Pharmacology · doi:10.2174/1875044301205010001 · Cited by 151
Metadata
- Authors
- van Aalten, D. M. F., Synstad, B., Brurberg, M. B., Hough, E., Riise, B. W., Eijsink, V. G. H., & Wierenga, R. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-05-23
- Volume
- 97
- Issue
- 11
- Pages
- 5842-5847
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2155082155
- Cited by
- 265
- References
- 2
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
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- van Aalten, D. M. F., Synstad, B., Brurberg, M. B., Hough, E., Riise, B. W., Eijsink, V. G. H., & Wierenga, R. K. (2000). Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-Å resolution. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.11.5842
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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