The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intergeneric poliovirus recombinants for the treatment of malignant glioma
Open accessAbstract
Poliovirus neuropathogenicity depends on sequences within the 5′ nontranslated region of the virus. Exchange of the poliovirus internal ribosomal entry site with its counterpart from human rhinovirus type 2 resulted in attenuation of neurovirulence in primates. Despite deficient virus propagation in cells of neuronal origin, nonpathogenic polio recombinants retain excellent growth characteristics in cell lines derived from glial neoplasms. Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. Intergeneric polio recombinants with heterologous internal ribosomal entry site elements unfolded strong oncolytic potential against experimentally induced gliomas in athymic mice. Our observations suggest that highly attenuated poliovirus recombinants may have applicability as biotherapeutic antineoplastic agents.
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Gromeier, M., Alexander, L., & Wimmer, E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2370 · Cited by 330
Self-citationDual Stem Loops within the Poliovirus Internal Ribosomal Entry Site Control Neurovirulence
Gromeier, M., Bossert, B., Arita, M., Nomoto, A., & Wimmer, E. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.958-964.1999 · Cited by 160
Self-citation
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Metadata
- Authors
- Gromeier, M., Lachmann, S., Rosenfeld, M. R., Gutin, P. H., & Wimmer, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-06-06
- Volume
- 97
- Issue
- 12
- Pages
- 6803-6808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2050216826
- Cited by
- 363
- References
- 2
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Gromeier, M., Lachmann, S., Rosenfeld, M. R., Gutin, P. H., & Wimmer, E. (2000). Intergeneric poliovirus recombinants for the treatment of malignant glioma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.12.6803
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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