The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M 3 subtype
Open accessAbstract
Muscarinic acetylcholine receptors consist of five distinct subtypes and have been important targets for drug development. In the periphery, muscarinic acetylcholine receptors mediate cholinergic signals to autonomic organs, but specific physiological functions of each subtype remain poorly elucidated. Here, we have constructed and analyzed mutant mice lacking the M 3 receptor and have demonstrated that this subtype plays key roles in salivary secretion, pupillary constriction, and bladder detrusor contractions. However, M 3 -mediated signals in digestive and reproductive organs are dispensable, likely because of redundant mechanisms through other muscarinic acetylcholine receptor subtypes or other mediators. In addition, we have found prominent urinary retention only in the male, which indicates a considerable sex difference in the micturition mechanism. Accordingly, this mutant mouse should provide a useful animal model for investigation of human diseases that are affected in the peripheral cholinergic functions.
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Cited by
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Wess, J., Eglen, R. M., & Gautam, D. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2379 · Cited by 637
Abrams, P., Andersson, K., Buccafusco, J. J., Chapple, C., de Groat, W. C., Fryer, A. D., Kay, G., Laties, A., Nathanson, N. M., Pasricha, P. J., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706780 · Cited by 632
Neural Control of the Lower Urinary Tract
de Groat, W. C., Griffiths, D., & Yoshimura, N. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130056 · Cited by 553
Genetic approaches to studying energy balance: perception and integration
Barsh, G. S., & Schwartz, M. W. (2002) · Nature Reviews Genetics · doi:10.1038/nrg862 · Cited by 416
Antimuscarinics for treatment of overactive bladder
Andersson, K.-E. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00622-7 · Cited by 414
Metadata
- Authors
- Matsui, M., Motomura, D., Karasawa, H., Fujikawa, T., Jiang, J., Komiya, Y., Takahashi, S.-I., & Taketo, M. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-08-15
- Volume
- 97
- Issue
- 17
- Pages
- 9579-9584
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007829947
- Cited by
- 450
- References
- 21
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Matsui, M., Motomura, D., Karasawa, H., Fujikawa, T., Jiang, J., Komiya, Y., Takahashi, S.-I., & Taketo, M. M. (2000). Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M 3 subtype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.17.9579
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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