The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Involvement of decidual Vα14 NKT cells in abortion
Open accessAbstract
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by Vα14/Jα281 and Vβ7 segments, accumulated in the decidua during pregnancy and provoked abortion upon stimulation with α-galactosylceramide (α-GalCer), a specific ligand for Vα14 NKT cells. The α-GalCer-mediated abortion was not observed in Vα14 NKT-, IFN-γ-, tumor necrosis factor α-, or perforin-knock-out mice and appeared to be due to the degeneration of embryonic trophoblasts mediated by the activated Vα14 NKT cells whose perforin-dependent killing and production of IFN-γ and tumor necrosis factor α were essential. The possible role of the decidual Vα14 NKT cells in the pathogenesis of abortion is discussed.
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Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
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Natural killer T cell subsets in eutopic and ectopic endometrium: a fresh look to a busy corner
Laganà, A. S., Triolo, O., Salmeri, F. M., Granese, R., Palmara, V. I., Ban Frangež, H., Vrtčnik Bokal, E., & Sofo, V. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-4004-7 · Cited by 67
Metadata
- Authors
- Ito, K., Karasawa, M., Kawano, T., Akasaka, T., Koseki, H., Akutsu, Y., Kondo, E., Sekiya, S., Sekikawa, K., Harada, M., Yamashita, M., Nakayama, T., & Taniguchi, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-01-18
- Volume
- 97
- Issue
- 2
- Pages
- 740-744
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113047400
- Cited by
- 169
- References
- 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Ito, K., Karasawa, M., Kawano, T., Akasaka, T., Koseki, H., Akutsu, Y., Kondo, E., Sekiya, S., Sekikawa, K., Harada, M., Yamashita, M., Nakayama, T., & Taniguchi, M. (2000). Involvement of decidual Vα14 NKT cells in abortion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.2.740
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