The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cationic microparticles: A potent delivery system for DNA vaccines
Open accessAbstract
An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection. The microparticles released intact and functional DNA over 2 weeks in vitro . In addition, the microparticles induced higher levels of marker gene expression in vivo . After i.m. immunization, the microparticles induced significantly enhanced serum antibody responses in comparison to naked DNA. Moreover, the level of antibodies induced by the microparticles was significantly enhanced by the addition of a vaccine adjuvant, aluminum phosphate. In addition, in contrast to naked DNA, the cationic microparticles induced potent cytotoxic T lymphocyte responses at a low dose.
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Cites
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Biologically erodable microspheres as potential oral drug delivery systems
Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823
Cited by
Targeting dendritic cells with biomaterials: developing the next generation of vaccines
Reddy, S. T., Swartz, M. A., & Hubbell, J. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.005 · Cited by 406
Distribution of DNA Vaccines Determines Their Immunogenicity After Intramuscular Injection in Mice
Dupuis, M., Denis-Mize, K., Woo, C., Goldbeck, C., Selby, M. J., Chen, M., Otten, G. R., Ulmer, J. B., Donnelly, J. J., Ott, G., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2850 · Cited by 327
Self-citationPerez, C., Sanchez, A., Putnam, D., Ting, D., Langer, R., & Alonso, M. J. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00397-2 · Cited by 313
In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287
Recent advancement of gelatin nanoparticles in drug and vaccine delivery
Sahoo, N., Sahoo, R. K., Biswas, N., Guha, A., & Kuotsu, K. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.08.006 · Cited by 270
Metadata
- Authors
- Singh, M., Briones, M., Ott, G., & O'Hagan, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-01-18
- Volume
- 97
- Issue
- 2
- Pages
- 811-816
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097738098
- Cited by
- 489
- References
- 3
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- green
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